circRNAs

circRNAs catalogs circular RNAs detected in human body fluids (plasma, serum, exosomes, urine) to support cancer biomarker discovery and liquid biopsy research.

Key Features:

• Database Content: Compiles circRNAs identified in plasma, serum, exosomes, and urine and records their reported expression and stability in these fluids.
• Cancer Biomarker Potential: Highlights differential circRNA expression between cancer patients and healthy individuals to facilitate selection of candidate biomarkers for diagnosis and monitoring via liquid biopsy.
• Pan-Cancer Dataset Integration: Synthesizes circRNA data across multiple cancer types to enable comparative and pan-cancer analyses of marker prevalence and specificity.

Scientific Applications:

• Cancer Diagnosis and Prognosis: Identification of circRNA candidates in body fluids for sensitive and specific liquid biopsy-based early detection and disease monitoring.
• Pan-Cancer Analysis: Comparative studies across cancer types to discover universal or tumor-type-specific circRNA markers.

Methodology:

Data derived from high-throughput transcriptome analysis of body fluids; the database synthesizes findings from a pan-cancer dataset to characterize the clinical relevance of circRNAs.