circVAR database

circVAR database provides a genome-wide catalog of genetic variants within human circular RNAs (circRNAs) to support analysis of their potential regulatory roles and disease associations.

Key Features:

• Extensive Genetic Annotation: Integrates annotations for 295,526 circRNAs from circBase, circNet, and circRNAdb.
• Chromosome-Based Distribution Analysis: Reports circRNA distribution across chromosomes and highlights enrichment on chromosome 17 and complex somatic mutation patterns on chromosome 7.
• Integration with Major Databases: Maps circRNA variants to the 1000 Genomes Project and ClinVAR for population and clinical context.
• GWAS and Somatic Variant Annotation: Annotates GWAS signals and cancer somatic variants to identify non-coding and complex mutations in circRNA regions.
• Phenotypic Information Correlation: Collects SNPs and small insertions/deletions (INDELs) within circRNA loci to associate variants with phenotypic information.

Scientific Applications:

• Regulatory mechanism analysis: Analyze how circRNA variants may affect miRNA binding and RNA binding protein interactions and thereby influence gene regulation.
• Disease association discovery: Link circRNA-associated variants from GWAS and ClinVAR mappings to complex traits and clinical phenotypes.
• Cancer mutation characterization: Investigate somatic and complex mutations in circRNA regions, including chromosome 7 somatic variant patterns relevant to cancer research.

Methodology:

Integrates circRNA entries from circBase, circNet, and circRNAdb; maps variants to the 1000 Genomes Project and ClinVAR; annotates GWAS and somatic variants; and collects SNPs and INDELs within circRNA regions.