CIViC

CIViC provides a crowd-sourced knowledgebase that aggregates literature-derived clinical evidence to support interpretation of somatic and germline cancer variants.

Key Features:

• Evidence Items: Aggregates peer-reviewed, published literature into structured Evidence Items representing variant-level clinical evidence.
• Curation and moderation: Evidence Items are curated and expert-moderated to ensure accuracy and relevance of interpretations.
• Evidence Types: Implements Predisposing, Oncogenic, and Functional Evidence Types to capture a spectrum of variant effects.
• Somatic and germline integration: Integrates both somatic and germline variant knowledge to inform cancer predisposition, oncogenesis, and drug response.
• Guideline alignment and interoperability: Aligns content with emergent variant interpretation guidelines and improves interoperability with other genomic resources.
• Curated content scope: Contains curated data covering over 3,200 variants across more than 470 genes from over 3,100 publications and supported by a community of over 300 contributors.

Scientific Applications:

• Clinical variant interpretation: Supports interpretation of cancer-associated variants for clinical decision-making.
• Personalized medicine: Informs individualized oncology treatment decisions by linking variants to clinical evidence.
• Drug response inference: Enables inference of potential drug responses based on functional and oncogenic evidence.
• Predisposition and oncogenesis research: Facilitates investigation of germline predisposition and somatic mechanisms of oncogenesis.
• Resource integration: Enhances interoperability for integration with other genomic resources and workflows.

Methodology:

Aggregates peer-reviewed publications into structured Evidence Items that are curated and expert-moderated, categorizes evidence into Predisposing, Oncogenic, and Functional types, and aligns entries with variant interpretation guidelines to improve interoperability.