CKTTD

CKTTD compiles and curates immune checkpoint targets and their modulators to support cancer immunotherapy research and drug discovery.

Key Features:

• Comprehensive target collection: Compiles checkpoint protein targets, microRNAs (miRNAs), long non-coding RNAs (LncRNAs), and modulators including small molecules and antibodies.
• Validated content: Includes 105 checkpoint protein targets, 53 modulators, 30 miRNAs, and 18 LncRNAs supported by experimental evidence.
• Scoring system: Employs a scoring system to filter and present high-confidence targets.
• Data integration: Integrates information from Oncomine, Drugbank, miRBase, and Lnc2Cancer.
• Ligand-binding site data: Provides ligand-binding site information for all included targets.
• Literature curation: Curates experimental evidence from 10,649 literature sources using an enhanced text-mining system.

Scientific Applications:

• Cancer immunotherapy target identification: Supports identification and prioritization of immune checkpoint targets for cancer immunotherapy research.
• Drug discovery and modulator selection: Supports small-molecule and antibody discovery through curated modulators and ligand-binding site information.
• Translational research support: Provides experimentally validated targets to inform translational studies and experimental target selection.

Methodology:

Data were integrated from Oncomine, Drugbank, miRBase, and Lnc2Cancer; experimental evidence was curated from 10,649 literature sources using an enhanced text-mining system; a scoring system was applied to filter and present high-confidence targets; ligand-binding site information was compiled for included targets.