Clinical Trials Information Mediator

Clinical Trials Information Mediator mediates integrated access to ClinicalTrials.gov, PubMed, and BioSamples to enable cross-domain discovery of clinical trials, related publications, and biosample metadata.

Key Features:

• Data integration: Integrates and indexes records from ClinicalTrials.gov, PubMed, and BioSamples for unified cross-domain retrieval.
• Linked data principles: Applies linked data principles to connect entities across clinical trials, publications, and biosamples.
• Clinical trial–centered search: Implements a clinical trial–centered search approach that prioritizes trial-centric links to associated literature and biosamples.
• Enhanced retrieval of interconnected data: Improves retrieval of associated publications and biosamples compared to isolated database searches.
• Open-source implementation: Implemented using open-source technology.
• Validation: Demonstrated capability across three use cases to streamline complex queries and increase retrieval of pertinent information.

Scientific Applications:

• Cross-domain discovery: Enables discovery of publications and biosamples associated with specific clinical trials.
• Evidence aggregation: Facilitates aggregation of trial-centered evidence linking trial records, research publications, and biosample metadata.
• Query streamlining: Streamlines complex multi-database query processes to reduce time for data retrieval.
• Use-case benchmarking: Supports evaluation and benchmarking of retrieval strategies using defined use cases.

Methodology:

Integrates data from ClinicalTrials.gov, PubMed, and BioSamples, applies linked data principles to connect records, and implements a clinical trial–centered search strategy; developed and implemented using open-source technology.