ClonoMatch

ClonoMatch identifies homologous immunoglobulin (Ig) and T cell receptor (TCR) sequences within large AIRR-seq databases by matching CDR3 and V3J clonotypes to support analysis of adaptive immune repertoires.

Key Features:

• Clonotype Matching: Accepts V3J clonotypes and searches AIRR-seq datasets for similar B cell receptor (BCR) and T cell receptor (TCR) sequences with focus on the CDR3 region.
• Single and Multiple Clonotype Searches: Supports single clonotype queries and batch processing of multiple clonotypes from files for large-scale analyses.
• Scalability and Efficiency: Optimized for next-generation sequencing (NGS) scale immunome datasets, enabling searches across millions of sequences.

Scientific Applications:

• Adaptive immune repertoire analysis: Identification and comparison of clonotypes in AIRR-seq datasets to characterize repertoire composition.
• Antigen recognition and specificity studies: Investigation of the molecular basis of antibody-antigen and TCR-peptide interactions by focusing on CDR3 sequences.
• BCR and TCR repertoire characterization: Analysis of B-cell receptor and T-cell receptor repertoires generated by somatic DNA rearrangements.

Methodology:

ClonoMatch applies sequence analysis techniques to perform rapid searches of bulk immunome data, explicitly processing and comparing CDR3 sequences and V3J clonotypes.