cmvdrg

cmvdrg performs antiviral drug resistance genotyping for Human Cytomegalovirus (HCMV) from Sanger and Next-Generation Sequencing (NGS) data as an R package.

Key Features:

• Resistance Mutation Database: Built on HerpesDRG, a curated database of known resistance-conferring mutations across significant genes and current treatment options for human herpesviruses (HHVs) compiled from genotype-to-phenotype literature.
• Sequencing Input Support: Processes Sanger and Next-Generation Sequencing (NGS) data for variant detection and analysis.
• Variant Annotation: Annotates detected variants against the HerpesDRG database to identify resistance-associated mutations.
• Clinical Interpretation: Provides clinical implication analysis to interpret the impact of mutations on antiviral resistance.
• Implementation: Implemented as an R package offering programmatic access to annotation and analysis functions.

Scientific Applications:

• Drug Development and Management: Identifies resistance-conferring mutations to inform antiviral drug development and treatment strategy decisions for HCMV.
• Research and Clinical Studies: Enables research and clinical investigations into the genetic basis of HCMV antiviral resistance and viral evolution.

Methodology:

Integrates the HerpesDRG database compiled from a systematic review of genotype-to-phenotype studies and applies variant annotation and clinical-implication analysis to Sanger and NGS sequencing data.