CNpare

CNpare compares genome-wide tumor DNA copy number profiles to identify cancer cell line models with similar DNA copy number variation patterns for use in cancer research.

Key Features:

• Genome-wide DNA copy number analysis: Performs comprehensive analysis across entire genomes focusing on DNA copy number profiles.
• Cell line model identification: Compares genome-wide DNA copy number profiles to identify cancer cell line models similar to tumor samples.
• R package implementation: Implemented as an R package to operate within R-based bioinformatics environments.

Scientific Applications:

• Cell line selection: Enables selection of cancer cell lines that closely match the DNA copy number landscapes of tumors.
• Tumor biology and translational studies: Supports comparative analyses of tumor genetics relevant to studies of tumor biology, drug response, and personalized medicine.

Methodology:

Analyzes genome-wide DNA copy number variations and compares copy number profiles between tumor samples and cell lines to identify similarities; implemented in R.