CoCoMaps

CoCoMaps visualizes intermolecular contact maps to analyze and characterize interfaces in protein–protein, protein–DNA, and protein–RNA complexes.

Key Features:

• Integrative Analysis: Combines traditional analytical techniques with 3D visualization methods to examine molecular interfaces.
• Intermolecular Contact Maps: Uses contact maps to represent residue- and nucleotide-level interaction sites between interacting partners.
• Comparative Capabilities: Enables comparison of different complexes or interfaces to reveal structural similarities and differences.

Scientific Applications:

• Interface characterization: Analysis of protein–protein, protein–DNA, and protein–RNA interfaces to identify interaction sites and interface composition.
• Molecular biology and biochemistry research: Dissection of interaction patterns and spatial relationships relevant to mechanism and function.
• Structure-guided drug design: Identification of interaction hotspots and contact networks to inform targeted therapeutic development.

Methodology:

Generates and analyzes intermolecular contact maps and combines traditional analytical techniques with 3D visualization methods to examine spatial relationships between interacting molecules.