CohesinDB

CohesinDB integrates extensive multiomics datasets related to cohesin to enable exploration of cohesin binding sites, cohesin-associated chromatin loops, and cis-regulatory modules for studies of transcriptional regulation and 3D genome organization.

Key Features:

• Multiomics Integration: Amalgamates 2,043 datasets encompassing epigenomics, transcriptomics, and 3D genomics consolidated from 530 studies across 176 cell types.
• Cohesin Objects: Categorizes data into three primary cohesin objects—Cohesin Binding Sites (over 751,590 sites), Cohesin-Related Chromatin Loops (over 957,868 entries), and Cohesin-Related Cis-Regulatory Modules (over 2,229,500 CRMs).
• Functional Annotations: Annotates each cohesin object with locus information, cell type specificity, classification, putative functional implications, and associated 3D genomic structures.

Scientific Applications:

• Chromatin dynamics and gene regulation: Supports investigation of cohesin's roles in chromatin dynamics and gene regulation using integrated multiomics evidence.
• Transcriptional regulation analysis: Enables linking cohesin binding sites, CRMs, and chromatin loops to transcriptomic data to study cohesin-mediated transcriptional control.
• Epigenomic landscape profiling: Facilitates comparison of epigenomic contexts of cohesin features across cell types using integrated epigenomics datasets.
• 3D genome organization studies: Supports analysis of 3D genome architecture by cataloging cohesin-related chromatin loops and associated 3D genomic structures.
• Tissue-specific function and development: Enables examination of tissue-specific cohesin functions and their impact on cellular differentiation and development across 176 cell types.

Methodology:

Integrates 2,043 next-generation sequencing–derived datasets from 530 studies across 176 cell types by synthesizing epigenomics, transcriptomics, and 3D genomics data into unified cohesin object annotations.