combPDX

combPDX provides a statistical framework to evaluate drug synergism from patient-derived xenograft (PDX) tumor growth curve data for preclinical assessment of combination cancer therapies.

Key Features:

• Statistical framework for synergism evaluation: Implements a comprehensive statistical approach to assess drug synergism in PDX experiments beyond single dose levels.
• Advanced metrics and robust inference: Computes advanced metrics and applies robust statistical inference procedures to quantify combination effects.
• Temporal analysis (local and global): Evaluates combination effects locally at specific time points and globally across the entire experiment duration.
• Integration with classical drug interaction models: Incorporates classical drug interaction models to interpret combination effects within a pharmacological framework.
• Integration of genomic and pharmacological profiles (NSCLC): Supports linking PDX drug response data with genomic and pharmacological profiles as demonstrated in non-small-cell lung cancer (NSCLC) studies.
• Power calculations for experimental design: Includes power calculation capabilities to inform design and interpretation of PDX combination experiments.

Scientific Applications:

• Drug Development: Quantifies combination efficacy in preclinical PDX studies to support optimization of anticancer combination therapies.
• Translational Research: Provides analytical evidence of drug interactions in PDX models to inform translation from preclinical models to clinical hypotheses.
• Personalized Medicine: Enables integration of genomic and pharmacological data to support identification of patient-tailored combination strategies.

Methodology:

Analyzes PDX tumor growth curve data using statistical models and advanced metrics, applies robust statistical inference, evaluates local (timepoint) and global (whole-duration) effects, incorporates classical drug interaction models, considers temporal and spatial aspects of interactions, integrates genomic and pharmacological profiles, and performs power calculations.