CoMutDB

CoMutDB characterizes somatic mutation co-occurrence in cancer by aggregating and cataloging multi-omics data from over 30,000 subjects and 1,747 cancer cell lines.

Key Features:

• Comprehensive Data Collection: Aggregates somatic mutation data from over 30,000 subjects and 1,747 cancer cell lines across diverse cancer types.
• Multi-Omics Integration: Integrates data from multiple omic layers to enable analysis of interactions between different molecular datasets.
• Catalog of Co-mutation Pairs: Systematically catalogs somatic mutation pairs with associated characteristics and contextual information for each co-mutation event.
• Centralized Co-mutation Resource: Provides a dedicated, centralized repository focused specifically on cancer co-mutations to support comparative analyses across samples.

Scientific Applications:

• Tumorigenesis Research: Enables exploration of how somatic co-mutations contribute to cancer development, progression, and heterogeneity.
• Target Identification: Supports identification of mutation pairs that may drive oncogenic processes and serve as targets for therapeutic investigation.
• Biomarker Discovery: Facilitates discovery of co-occurrence patterns that can serve as biomarkers for specific cancer types or subtypes.

Methodology:

Integration of multi-omics data and systematic cataloging of somatic mutation pairs across diverse cancer samples with associated characteristics and context.