ConjuPepDB

ConjuPepDB catalogs peptide-drug conjugates and their chemical and biomedical metadata to support research on targeted delivery, linker design, and therapeutic efficacy.

Key Features:

• Database scope: Contains over 1,600 peptide-drug conjugates compiled from approximately 230 publications.
• Component annotation: Records the three constituent components of conjugates: the small drug molecule, the peptide providing site-specificity, and the chemical linker (including biodegradable linkers).
• Chemical identifiers: Includes CAS numbers and chemical structures for recorded conjugates.
• Conjugation chemistry: Documents types of chemical conjugation employed for linking drugs to peptides.
• Biomedical metadata: Captures reported biomedical applications associated with each conjugate.
• Curation and annotation: Entries are curated and annotated by experts to ensure accuracy of extracted data.

Scientific Applications:

• Targeted delivery and site-specificity: Supports investigation of peptide-mediated targeting strategies for site-specific drug delivery.
• Controlled release studies: Enables analysis of linkers, including biodegradable linkers, that facilitate controlled drug release.
• Design and optimization: Provides reference data for design and optimization of peptide-drug conjugates and linker selection.
• Conjugation strategy assessment: Facilitates comparison of chemical conjugation methods used in peptide-drug conjugates.
• Drug development and biomedical research: Serves as a dataset to inform preclinical development and biomedical research on therapeutic efficacy and side-effect mitigation.

Methodology:

Entries were manually curated and annotated from approximately 230 publications.