Cone snail toxin database ConoServer

Cone snail toxin database ConoServer catalogs conopeptide nucleotide and protein sequences, associated three-dimensional structures, and annotated post-translational modifications to support research on Conus-derived peptides that modulate ion channels and serve as drug leads and physiological probes.

Key Features:

• Content: Contains 1,214 nucleic acid sequences from 54 Conus species, 2,258 protein sequences from 66 species, and 99 three-dimensional structures.
• Classification and nomenclature: Employs a standardized nomenclature system and genetic and structural classification scheme to organize conopeptides.
• Data sources: Integrates sequence and structure data from SwissProt, GenBank, the Protein Data Bank (PDB), and the scientific literature.
• Post-translational modification annotation: Annotates and represents post-translational modifications that contribute to conopeptide diversity and biological activity.
• Structure-sequence linkage: Links three-dimensional structures to corresponding nucleotide and protein sequence entries and modification data.

Scientific Applications:

• Drug discovery: Supports identification and characterization of conopeptide drug leads and structure-activity relationships.
• Ion channel research: Enables studies of conopeptide modulation of ion channels and related functional effects.
• Basic research in pharmacology, neurobiology, and biochemistry: Serves as a curated resource for investigating physiological roles and biochemical properties of conopeptides.

Methodology:

Employs a standardized nomenclature system and genetic and structural classification scheme, integrates data from SwissProt, GenBank, the Protein Data Bank (PDB) and scientific literature, stores nucleotide and protein sequences and three-dimensional structures, and annotates post-translational modifications.