ConPlot

ConPlot visualizes and integrates residue contact maps and distograms derived from covariance-based predictions to aid interpretation of protein structural and functional information.

Key Features:

• Visualization: Displays contact maps and distograms derived from covariance-based predictions to represent predicted inter-residue contacts and distance distributions.
• Integration with Other Data: Integrates sequence-derived predictions—secondary structure, transmembrane helical topology, and sequence conservation—using multiple colored tracks near the contact-map diagonal.
• Data Compatibility: Imports popular file formats and bespoke datasets to accommodate diverse contact and distogram prediction outputs.

Scientific Applications:

• Protein structure prediction: Aids interpretation of predicted inter-residue contacts and distances for structure modeling.
• Folding mechanism analysis: Facilitates analysis of residue-residue interaction patterns relevant to protein folding studies.
• Functional annotation: Supports inference of functional sites and structural dynamics by integrating contact/distance predictions with secondary-structure and conservation data.

Methodology:

Leverages covariance-based methods to predict residue contacts and distances and integrates those predictions with sequence-derived data such as secondary structure, transmembrane helical topology, and sequence conservation.