CONREL

CONREL annotates consensus regulatory elements in the human genome by integrating transcription factor binding motif affinities with 1000 Genomes Project genotype data to characterize consensus promoters, enhancers, and active enhancers.

Key Features:

• Functional annotation at multiple levels: Provides functionally annotated transcriptional consensus regulatory elements including consensus promoters, enhancers, and active enhancers across levels of abstraction.
• Extensive data collection: Assembles consensus regulatory elements derived from 198 cell lines spanning 38 tissue types and aggregated global consensuses.
• Integration with genotype and motif affinity data: Integrates genotype data from the 1000 Genomes Project with total binding affinity of thousands of transcription factor binding motifs at genomic regulatory elements to enable detailed characterization and functional annotation.
• Comparative analysis capability: Facilitates comparison with other available resources to assess data comprehensiveness and analytical depth.

Scientific Applications:

• Gene regulatory network elucidation: Uses transcription factor binding affinities and interactions with regulatory elements to support mapping of gene regulatory networks.
• Genomic loci exploration: Enables investigation of specific genomic loci across different cell lines and tissue types to study tissue-specific gene regulation.
• Cross-tissue comparative studies: Supports comparative analyses across tissues using its extensive dataset to examine regulatory element functionality in diverse biological contexts.

Methodology:

Integrates 1000 Genomes Project genotype data with total binding affinity calculations of thousands of transcription factor binding motifs to annotate and characterize consensus promoters, enhancers, and active enhancers.