cons (EBI)

cons (EBI) generates consensus sequences from protein or nucleotide multiple alignments to identify conserved motifs and representative residues for evolutionary, structural, and functional analyses.

Key Features:

• Consensus sequence generation: Produces consensus sequences from aligned protein or nucleotide sequences.
• Input types: Accepts multiple sequence alignments of proteins and nucleotides.
• EMBL-EBI integration: Operates within the EMBL-EBI Job Dispatcher framework and integrates with UniProt, InterPro, ENA (European Nucleotide Archive), and Ensembl Genomes.
• Programmatic access: Provides RESTful and SOAP-based APIs for automated submission and retrieval of jobs.

Scientific Applications:

• Evolutionary biology: Enables identification of conserved and variable positions across taxa to study conservation and divergence.
• Functional genomics: Identifies conserved motifs or domains to assist prediction of protein or gene function.
• Structural biology: Provides consensus-derived residues and motifs to inform protein structure modeling and identification of conserved structural elements.

Methodology:

Generates consensus sequences from protein or nucleotide multiple alignments and is integrated in the EMBL-EBI Job Dispatcher framework with access via RESTful and SOAP APIs.