CONTINUITY

CONTINUITY performs surface-based processing and visualization of brain connectome data for detailed neuroimaging and connectivity analyses.

Key Features:

• Automated processing pipeline: Integrates structural-to-diffusion image co-registration, surface reconstruction for subcortical structures, and fiber tractography in a single workflow.
• Surface-based methodologies: Operates primarily on brain and subcortical surfaces for processing and analysis.
• Probabilistic tractography: Implements three distinct probabilistic tractography methods using FSL, MRtrix, and DIPY.
• Tractography initialization: Uses brain and subcortical surfaces to initialize tractography algorithms for precise pathway mapping.
• Visualization types: Provides interactive plot types including hierarchical edge bundling circle plots and mapping results onto 2D/3D brain templates.
• External connectome compatibility: Accepts and processes connectome matrices generated by other tools and pipelines.

Scientific Applications:

• Brain connectome analysis: Mapping and analysis of neural pathways and network topology using surface-based tractography.
• Neuroimaging studies: Detailed surface-based investigations of brain structure and connectivity at cortical and subcortical levels.
• Neurological disorder research: Investigation of connectivity alterations associated with neurological and neuropsychiatric disorders.
• Computational neuroscience: Comparison and analysis of connectome matrices and tractography outputs for methodological studies.

Methodology:

Automated pipeline performing structural-to-diffusion image co-registration, surface reconstruction for subcortical structures, and probabilistic fiber tractography using three methods implemented via FSL, MRtrix, and DIPY; tractography is initialized from brain and subcortical surfaces, and results can be visualized with hierarchical edge bundling circle plots or mapped onto 2D/3D brain templates while accepting external connectome matrices.