CoralP

CoralP visualizes and analyzes the human phosphatome to represent protein phosphatase attributes and support interpretation of quantitative and qualitative proteomic, genomic, epidemiological, and high-throughput screening data.

Key Features:

• Phosphatome visualization: Generates visual representations of the human phosphatome focused on protein phosphatases to display family-level relationships.
• Visual encodings: Maps phosphatase attributes to edge color, node color, and node size for simultaneous quantitative and qualitative data representation.
• Multiple layouts: Supports phosphatome tree, radial network, and force-directed network layouts for alternative views of phosphatase relationships.
• Data integration: Accepts and encodes data from proteomic, genomic, epidemiological, and high-throughput screening experiments.
• Publication-quality output: Produces customizable visual representations intended for inclusion in scientific publications.

Scientific Applications:

• Phosphatase family contextualization: Situates individual protein phosphatases within the broader phosphatome to assess family relationships.
• Specificity and activity analysis: Enables exploration of phosphatase specificity and activity patterns across datasets.
• Signaling research: Facilitates analysis of phosphatase roles and interactions relevant to signaling pathways and disease mechanisms.
• Integrative dataset interpretation: Supports interpretation and comparison of proteomic, genomic, epidemiological, and high-throughput screening data mapped onto the phosphatome.

Methodology:

Implements phosphatome tree, radial network, and force-directed network visualizations and encodes attributes via edge color, node color, and node size.