CORDITE

CORDITE aggregates and curates published drug–virus interaction data for SARS-CoV-2 to support analysis of potential therapeutics, including drug repurposing and de novo drug design.

Key Features:

• Data curation: Curates and aggregates published drug–SARS‑CoV‑2 interaction data from experimental and clinical studies.
• Drug repurposing focus: Collates candidate repurposing drugs with reported activity and available safety profile information.
• De novo drug design support: Compiles compound and interaction data relevant to de novo drug design efforts.
• Evidence integration: Synthesizes results from multiple studies to provide consolidated evidence on potential therapeutics.
• Support for meta-analysis and clinical study design: Provides aggregated datasets suitable for meta-analyses and the design of clinical studies.
• Literature indexing: Indexes and links literature reports on SARS‑CoV‑2 drug interactions to facilitate evidence retrieval.

Scientific Applications:

• Drug repurposing research: Inform identification and evaluation of existing drugs as SARS‑CoV‑2 therapeutics.
• De novo drug discovery: Provide compiled interaction data to inform compound design and in silico screening.
• Meta-analysis: Enable meta-analyses of experimental and clinical evidence on drug efficacy and interactions.
• Clinical study design: Support selection and justification of compounds and endpoints for clinical trials.
• Virology and pharmacology research: Facilitate mechanistic and pharmacological investigations of SARS‑CoV‑2 drug interactions.

Methodology:

Curated aggregation of published SARS‑CoV‑2 drug interaction data from experimental and clinical studies.