CoreGenes3.5

CoreGenes3.5 identifies core genes within sets of viral and small bacterial genomes to support comparative genomics and phylogenetic analyses.

Key Features:

• Automated Batch Processing: Accepts multiple genome datasets for simultaneous analysis to determine conserved genes across sets of genomes.
• GenBank Accession Input: Accepts GenBank accession numbers as input for retrieval and analysis of genome sequences.
• Iterative BLASTP Analyses: Performs iterative BLASTP comparisons of protein sequences to detect genes conserved across the provided genomes.

Scientific Applications:

• Classification of Bacteriophage Genomes: Identification of core genes to inform bacteriophage classification and infer evolutionary relationships.
• Pathogen Genome Mining: Detection of conserved loci across pathogen genomes to support studies of virulence factors, resistance mechanisms, and potential therapeutic targets.

Methodology:

GenBank accession numbers are used to retrieve genomes and iterative BLASTP comparisons of predicted protein sequences across the provided genomes are performed to identify genes present in all analyzed genomes as core genes.