CoronaVR

CoronaVR provides integrated bioinformatics analyses for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) including genome analysis, epitope identification, siRNA/miRNA/sgRNA therapeutic candidate curation, and diagnostic primer design to support vaccine, therapeutic, and diagnostic research for COVID-19.

Key Features:

• Genomic Analysis: The "Genomes" section supplies genome browser views, phylogenetic analysis, codon usage patterns, glycosylation site mapping, and structural analyses of SARS-CoV-2 sequences.
• Epitope Identification: Reports cross-protective epitopes and predicts B-cell (linear/discontinuous) and T-cell (CD4+/CD8+) epitopes including cytotoxic T lymphocyte (CTL) and major histocompatibility complex (MHC) binders for vaccine candidate prioritization.
• Therapeutic Development: Curates and designs siRNA, miRNA, and sgRNA candidates, including experimentally confirmed and in silico–designed therapeutic sequences.
• Diagnostic Primers: Lists experimentally validated and newly designed diagnostic primers for SARS-CoV-2 detection.

Scientific Applications:

• Vaccine Development: Identification and prioritization of B-cell (linear/discontinuous) and T-cell (CD4+/CD8+) epitopes to support peptide- and epitope-based vaccine design and experimental testing for SARS-CoV-2.
• Therapeutic Interventions: Provision of curated siRNA, sgRNA, and miRNA candidate sequences to inform development of RNA-based therapeutic strategies.
• Diagnostic Tools: Compilation of experimentally validated and newly designed primers to support molecular diagnostic assay development for SARS-CoV-2.

Methodology:

Provides genome browser visualization, phylogenetic analysis, codon usage analysis, glycosylation site mapping, structural analyses, B-cell (linear/discontinuous) and T-cell (CD4+/CD8+, CTL, MHC binder) epitope prediction, and design/curation of siRNA, miRNA, sgRNA and diagnostic primers, including cataloging of experimentally validated sequences.