CORUM

CORUM catalogs experimentally verified mammalian protein complexes and annotates their subunit composition and functional information, with entries primarily from human (64%), mouse (16%), and rat (12%).

Key Features:

• Manually Curated Data: Entries are manually annotated from individual scientific studies and exclude data from high-throughput experiments.
• Extensive Dataset: CORUM 2.0 contains 2,837 protein complexes assembled from 3,198 distinct genes, representing approximately 16% of the human proteome's coding capacity.
• Detailed Annotations: Each entry provides complex name, subunit composition, functional information, and literature references documenting experimental characterization.
• Functional Annotation Mapping: Integration of Gene Ontology (GO) terms supplies annotations for biological processes, molecular functions, and cellular components.
• Cross-Referencing Capabilities: Entries include cross-references to Entrez Gene identifiers.
• Phylogenetic Conservation Analysis Tool: A phylogenetic conservation analysis assesses the presence of orthologous complex subunits across mammalian species and selected groups of organisms.

Scientific Applications:

• Functional Genomics: Supports analysis of gene function and interaction networks through annotated complex compositions.
• Systems Biology: Enables systems-level investigation of molecular machinery underlying cellular processes.
• Evolutionary Studies: Facilitates study of evolutionary conservation and divergence of protein complexes across species using phylogenetic comparisons.
• Drug Discovery and Development: Informs identification and characterization of protein-complex-associated drug targets.

Methodology:

Manual curation from individual scientific studies; mapping of Gene Ontology (GO) terms; cross-referencing to Entrez Gene identifiers; phylogenetic conservation analysis of orthologous complex subunits across species.