CoV-AbDab

CoV-AbDab aggregates a repository of antibodies and nanobodies documented to bind members of the betacoronavirus family, including SARS-CoV-2, to support research into antibody sequences, epitopes, and cross-neutralization.

Key Features:

• Extensive Data Collection: As of 5 August 2020, contains information on over 1,400 published and patented antibodies and nanobodies from 66 scientific papers and 21 patents, including 1,131 entries that bind SARS-CoV-2.
• Comprehensive Metadata: Records evidence of cross-neutralization, antibody/nanobody origin, full variable domain sequences where available, and germline assignments.
• Epitope and Structural Links: Annotates epitope regions and provides links to relevant Protein Data Bank (PDB) entries and available homology models.
• Cross-Species Coverage: Includes entries that bind other betacoronaviruses such as SARS-CoV-1 and MERS-CoV.

Scientific Applications:

• Vaccine Development: Supports evaluation of neutralizing antibodies and identification of epitope targets relevant to vaccine design.
• Diagnostic Development: Enables identification of antibodies suitable for use in assays to detect exposure to SARS-CoV-2 and other betacoronaviruses.
• Biotherapeutic Development: Provides sequence and epitope data to inform development of monoclonal antibody therapeutics and nanobody-based treatments.

Methodology:

Consolidates data from scientific literature and patents into a structured database that records sequences, germline assignments, epitope annotations, and links to PDB entries and homology models.