CoVex

CoVex integrates virus–human protein interactions, human protein–protein interactions, and drug–target interactions to enable network-based exploration of the SARS-CoV-2 host interactome and to prioritize drug repurposing candidates.

Key Features:

• Integration of diverse biological data: Consolidates virus–human protein interactions, human protein–protein interactions, and drug–target interaction data from SARS-CoV-2 studies.
• Systems medicine algorithms: Employs systems biology and network medicine algorithms to analyze the host interactome and generate network-based predictions.
• Network-based drug repurposing: Maps known drug targets onto the host interactome to identify and prioritize existing drugs for potential repurposing.
• Therapeutic target prioritization: Ranks candidate therapeutics by analyzing the interconnectedness of viral and host proteins using integrated datasets.

Scientific Applications:

• Elucidation of SARS-CoV-2 pathogenic mechanisms: Uses integrated interaction data to reveal molecular mechanisms underlying viral pathogenicity.
• Prioritization of candidate therapeutics: Applies network-based predictions to rank proteins and drugs for therapeutic investigation.
• Drug repurposing studies: Identifies mechanistic drivers of the virus life cycle to support repurposing of existing drugs.

Methodology:

Integrates virus–human interaction data with human protein–protein interaction networks and known drug–target interactions and applies systems biology and network medicine algorithms to predict and prioritize candidate drugs.