COVIC-DB

COVIC-DB compiles and standardizes blinded, side-by-side experimental data on anti-SARS-CoV-2 antibodies to enable comparative analysis of affinity, neutralization, in vivo protection, and effector functions.

Key Features:

• Systematic data collection and analysis: Aggregates blinded antibody samples tested side-by-side across multiple functional activities to reduce discrepancies from differing experimental setups.
• Comprehensive antibody profiling: Captures quantitative measures of affinity, neutralization capacity, in vivo protection, and effector functions for each antibody.
• Interactive data visualization: Generates interactive graphs for direct comparison of antibodies based on selected functional properties.
• Guidance for therapeutic design: Enables examination of correlations among antibody features to inform design and optimization of therapeutic antibody cocktails.

Scientific Applications:

• Therapeutic antibody development: Supports identification and optimization of candidate anti-SARS-CoV-2 therapeutic antibodies using standardized comparative data.
• Comparative studies: Facilitates standardized comparisons of relative antibody effectiveness across multiple functional assays.
• Strategic research planning: Informs research and development decisions by revealing relationships among antibody properties relevant to efficacy.

Methodology:

Systematic collection and computational analysis of blinded, side-by-side antibody data across multiple functional activities and generation of interactive comparative visualizations.