COVID-19 Knowledge Graph

COVID-19 Knowledge Graph encodes cause-and-effect relationships from scientific literature about SARS-CoV-2 pathophysiology into a computable knowledge graph for computational reasoning and hypothesis generation.


Key Features:

  • Multi-modal Knowledge Representation: Integrates diverse data types and sources to capture complex interactions within COVID-19 pathophysiology.
  • Cause-and-Effect Network: Focuses on causal relationships to represent how biological processes and factors contribute to disease progression and outcomes.
  • Computable Format: Provides a structured, machine-readable graph representation that enables computational analysis and large-scale hypothesis testing.

Scientific Applications:

  • Research Facilitation: Centralizes formalized knowledge to support individual and collaborative research on COVID-19 pathophysiology.
  • Data Exploration and Analysis: Enables large-scale computational exploration and analysis to identify novel connections and generate hypotheses about SARS-CoV-2 impacts.

Methodology:

Extracted knowledge from scientific publications and formalized it into a structured network of cause-and-effect relationships, then encoded the graph in multiple standard formats.

Topics

Collections

Details

License:
CC0-1.0
Tool Type:
library
Programming Languages:
Python
Added:
1/18/2021
Last Updated:
11/24/2024

Operations

Publications

Domingo-Fernández D, Baksi S, Schultz B, Gadiya Y, Karki R, Raschka T, Ebeling C, Hofmann-Apitius M, Kodamullil AT. COVID-19 Knowledge Graph: a computable, multi-modal, cause-and-effect knowledge model of COVID-19 pathophysiology. Unknown Journal. 2020. doi:10.1101/2020.04.14.040667.

Domingo-Fernández D, Baksi S, Schultz B, Gadiya Y, Karki R, Raschka T, Ebeling C, Hofmann-Apitius M, Kodamullil AT. COVID-19 Knowledge Graph: a computable, multi-modal, cause-and-effect knowledge model of COVID-19 pathophysiology. Bioinformatics. 2020;37(9):1332-1334. doi:10.1093/bioinformatics/btaa834. PMID:32976572. PMCID:PMC7558629.