COVID-KOP

COVID-KOP integrates the ROBOKOP knowledge graph with curated CORD-19 literature to enable biomedical reasoning for hypothesis generation and drug repurposing against SARS-CoV-2.

Key Features:

• Knowledge Graph Integration: Integrates the ROBOKOP knowledge graph with newly curated and annotated data from the CORD-19 collection.
• Biomedical Reasoning: Applies biomedical reasoning across integrated datasets to reveal connections among drugs, targets, pathways, and diseases.
• Drug Repurposing Focus: Supports hypothesis testing and exploration of known drugs and clinical drug candidates for repurposing against SARS-CoV-2.
• Rich Biomedical Content: Leverages ROBOKOP content on drug interactions, biological pathways, and disease mechanisms.
• CORD-19 Annotation: Incorporates annotations from recent COVID-19 research in the CORD-19 literature corpus.

Scientific Applications:

• Drug Repurposing: Identify and prioritize candidate drugs and clinical drug candidates for repurposing against SARS-CoV-2.
• Hypothesis Generation: Generate and evaluate mechanistic hypotheses linking drugs, targets, pathways, and disease mechanisms relevant to COVID-19.
• Therapeutic Prioritization: Prioritize potential therapeutic interventions and mechanisms for COVID-19 based on integrated knowledge from ROBOKOP and CORD-19.

Methodology:

Linking the ROBOKOP knowledge graph with curated and annotated CORD-19 datasets to enable knowledge-driven biomedical reasoning.