COVIDep

COVIDep identifies potential B-cell and T-cell epitopes for SARS-CoV-2 to support vaccine target selection by integrating experimentally-derived SARS-CoV epitope data with publicly available SARS-CoV-2 genetic sequences.

Key Features:

• Data Integration: Pools publicly available genetic sequences of SARS-CoV-2 with experimentally-derived epitope data from the 2003 SARS virus to nominate candidate epitopes.
• Flexibility: Accommodates updates as new SARS-CoV-2 sequences become available to maintain current epitope recommendations.
• Experimental Correlation: Correlates nominated epitopes with emerging experimental results to support validation of vaccine targets.

Scientific Applications:

• Vaccine target selection: Provides candidate B-cell and T-cell epitopes to guide SARS-CoV-2 vaccine target selection.
• Experimental planning: Supports design and planning of vaccine and immunological experiments by supplying experimentally-derived epitope recommendations.

Methodology:

Pools publicly available SARS-CoV-2 genetic sequences with epitope data from the 2003 SARS virus, updates recommendations as new sequences are added, and correlates outputs with emerging experimental results.