COVIEdb

COVIEdb provides a database of predicted B-cell and T-cell immune epitopes across SARS-CoV, MERS-CoV, 2019-nCoV (SARS-CoV-2), and RaTG13-CoV to support identification of vaccine targets and cross-reactive immunogenic regions.

Key Features:

• Epitope Prediction: Incorporates predictions of potential B-cell and T-cell epitopes based on protein sequences from multiple coronaviruses.
• Pan-Coronavirus Targets: Highlights epitopes with cross-reactivity potential, including sequences YFKYWDQTY in ORF1ab and VYDPLQPEL and TVYDPLQPEL in the spike (S) protein.
• Centralized Epitope Repository: Provides a consolidated collection of predicted epitopes across SARS-CoV, MERS-CoV, 2019-nCoV (SARS-CoV-2), and RaTG13-CoV to inform comparative analyses and vaccine target selection.

Scientific Applications:

• Vaccine design: Supports identification of conserved and cross-reactive epitopes for development of broad-spectrum coronavirus vaccines.
• Immunogenicity research: Enables exploration of immunogenic regions across SARS-CoV, MERS-CoV, 2019-nCoV (SARS-CoV-2), and RaTG13-CoV to inform studies of immune recognition and preparedness for emerging variants.

Methodology:

Predictions are derived from comprehensive analyses of viral protein sequences.