COXPRESdb

COXPRESdb provides gene coexpression networks for human, mouse, rat, chicken, zebrafish, fly, and nematode to identify conserved coexpression relationships and support functional and regulatory genomic analyses.

Key Features:

• Expanded Species Coverage: Includes coexpression data for human, mouse, rat, chicken, zebrafish, fly, and nematode to enable cross-species conservation analysis.
• Mutual Rank Coexpression Measure: Implements Mutual Rank as a coexpression metric to enhance comparability and reliability of coexpression relationships across samples and species.
• Integration of Omics Data Layers: Combines multiple omics data layers into gene networks to reduce noise and strengthen inferred coexpression signals.
• Functional and Regulatory Network Analysis: Represents gene networks to facilitate analysis of functional associations, regulatory interactions, and inferred protein-protein interaction contexts.

Scientific Applications:

• Gene Targeting and Functional Identification: Identification of candidate genes for experimental targeting based on coexpression relationships.
• Regulatory Mechanism Investigations: Analysis of coexpression networks to infer regulatory interactions and modules.
• Protein-Protein Interaction Networks: Exploration of potential protein-protein interaction contexts inferred from integrated coexpressed gene sets.

Methodology:

COXPRESdb quantifies coexpression using Mutual Rank and integrates diverse omics data layers to refine gene coexpression networks and reduce noise.