CPPsite1

CPPsite1 curates 843 experimentally validated cell-penetrating peptides (CPPs), short peptides of 10–30 amino acids, and their sequence-derived properties to support research on cellular uptake and therapeutic delivery.

Key Features:

• Database content: Contains 843 experimentally validated CPP entries compiled from scientific literature and patents.
• Peptide length: Records peptides ranging from 10 to 30 amino acids in length.
• ID: Provides a unique identifier for each peptide entry.
• PubMed ID: Links entries to relevant publications in the PubMed database.
• Peptide Name: Includes the designated name for each peptide.
• Peptide Sequence: Stores the amino acid sequence for each peptide.
• Chirality: Notes the stereochemistry of peptides where reported.
• Origin: Indicates whether peptides are synthetic or natural.
• Nature of Peptide: Classifies peptides based on reported properties and functions.
• Sub-cellular Localization: Records locations within cells where peptides localize.
• Uptake Efficiency: Records quantitative or qualitative data on cellular uptake efficiency.
• Uptake Mechanism: Records reported biological mechanisms of cellular entry.
• Hydrophobicity: Provides hydrophobicity measurements for peptides.
• Amino Acid Frequency and Composition: Reports amino acid frequencies and composition for each peptide.
• Structure and physicochemical predictions: Includes sequence-derived predictions of secondary and tertiary structures and computed physicochemical properties.
• Analyzing and mapping tools: Provides computational analyses and mapping of peptide sequence-derived properties.

Scientific Applications:

• Therapeutic delivery research: Provides experimentally validated peptide data to support delivery of therapeutic molecules into various cell types.
• Drug development and treatment strategies: Supports research on CPPs to advance drug development and treatment approaches.
• Predictive model development: Supplies sequence and physicochemical data for developing predictive models of CPP efficacy.
• Exploration of CPP utility: Enables comparative analyses of peptide properties and reported uptake mechanisms for biomedical applications.

Methodology:

Sequence-derived analyses include predictions of secondary and tertiary structures, calculation of physicochemical properties, and reporting of amino acid composition and frequency.