cProSite

cProSite provides comparative analysis of proteomics, phosphoproteomics, and genomics data to correlate protein and mRNA expression between tumor and normal tissues for studies associated with the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC).

Key Features:

• Fast Search Engine: Implements a rapid search engine to handle large-scale proteomics, phosphoproteomics, and genomics datasets.
• Data Integration: Integrates proteomics, phosphoproteomics, and genomics data to enable cross-omics comparisons and correlation of proteins and mRNAs.
• Clinical Data Validation: Supports validation of clinical data and identification of potential drug targets by comparing molecular profiles of tumor and normal tissues.

Scientific Applications:

• Drug Target Identification: Analyzes proteomic, phosphoproteomic, and genomic differences between tumor and normal tissues to inform identification of candidate drug targets.
• Research and Clinical Insights: Provides comparative molecular profiles to support research studies and clinical investigations of tumor biology.

Methodology:

Comparative analysis and correlation of proteomics, phosphoproteomics, and genomics data to assess protein–mRNA relationships between tumor and normal tissues within CPTAC datasets.