Crispi

Crispi catalogs CRISPR genomic structures and associated CRISPR-associated genes (CAS) across Archaea and Bacteria to support study of microbial adaptive immunity against plasmids and phages.

Key Features:

• Systematic database: A formal model using minimal parameters systematically identifies CRISPR occurrences across available genomes of Archaea and Bacteria.
• CRISPR-associated genes (CAS): Includes a complete repertoire of CRISPR-associated genes (CAS) for analysis of CRISPR functional diversity.
• CRISPR identification in input sequences: Identifies CRISPR structures within input nucleotide sequences.
• Sequence similarity with spacers: Performs sequence similarity calculations between spacers to support comparative and evolutionary analyses.

Scientific Applications:

• Genomic research: Enables exploration of the genetic architecture and evolutionary history of CRISPR systems across Archaea and Bacteria.
• Functional genomics: Supports functional studies of CRISPR mechanisms and their roles in microbial defense by providing CAS gene information.
• Comparative genomics: Facilitates comparative analyses of spacer sequences and CRISPR loci across species using sequence similarity metrics.

Methodology:

A formal model that captures CRISPR structures with minimal parameters is applied to systematically study CRISPR occurrences across available genomes of Archaea and Bacteria.