CRM web application

CRM web application implements the Bayesian Continual Reassessment Method (CRM) to perform simulation and adaptive dose-finding for phase I clinical trials.

Key Features:

• Simulation Component: The application generates simulated operating characteristics during study design to evaluate the accuracy, safety, and efficiency of CRM-based dose-finding.
• Implementation Component: It produces sequential dose recommendations based on accruing cohort- or patient-level data to adapt dosing decisions during trial conduct.
• Estimation of Maximum Tolerated Dose (MTD): It estimates the MTD at trial conclusion to identify the dose that balances efficacy and toxicity.

Scientific Applications:

• Phase I dose-finding: Supports the design and conduct of phase I clinical trials using Bayesian CRM for single-agent dose-escalation studies.
• Operating characteristic assessment: Enables evaluation and comparison of operating characteristics to inform trial design and safety assessment.
• Decision support for clinicians and reviewers: Aids interpretation of CRM outputs to support dose-escalation decisions and trial review.

Methodology:

Implements Bayesian statistical principles via the Continual Reassessment Method, using simulation of operating characteristics and sequential analysis of accruing data to generate adaptive dose recommendations.