CroCo

CroCo converts diverse cross-linking mass spectrometry (XL-MS) outputs into a standardized xTable (CSV) format to enable consistent downstream validation, visualization, and data exchange for protein cross-link analysis.

Key Features:

• Format Conversion: Converts results from multiple XL-MS search engines into the unified xTable (CSV) spreadsheet format.
• Parsing Diverse Outputs: Parses the varied output files produced by different cross-linking MS search engines to extract relevant cross-linking information.
• Integration for Downstream Tools: Produces xTable files that serve as input for validation and visualization tools used in XL-MS workflows.

Scientific Applications:

• Proteomics Data Standardization: Standardizes XL-MS outputs to support consistent comparative analyses across datasets and search engines.
• Protein Structure Determination: Facilitates validation and visualization workflows that contribute to deriving structural information from cross-link data.
• Protein–Protein Interaction Studies: Harmonizes cross-linking results to support interaction mapping and integrative analyses of protein complexes.

Methodology:

Parses output files from various XL-MS search engines and transforms them into a consistent xTable (CSV) format.