CSDB_GT

CSDB_GT catalogs experimentally validated glycosyltransferase (GT) activities across three non-animal model organisms to support comparative and functional analyses in glycoscience.

Key Features:

• Curated content: Near-complete coverage of experimentally validated glycosyltransferase (GT) activities compiled from the literature.
• Organism coverage: Includes Arabidopsis thaliana (~930 GT activities), Escherichia coli (~820 GT activities), and Saccharomyces cerevisiae (~270 GT activities).
• Taxonomic scope: Focuses on non-animal model organisms representing Plantae, Bacteria, and Fungi.
• Data specificity: Records are specific to GT activities rather than general gene annotations.
• Curation quality: Entries are manually curated to ensure reliability and experimental validation status.

Scientific Applications:

• Comparative glycoscience: Enables cross-species and cross-kingdom comparisons of GT activities to investigate functional diversity.
• Enzyme function prediction: Provides experimentally validated GT activities that can inform prediction and annotation of glycosyltransferases.
• Metabolic pathway analysis: Supplies GT activity data relevant for reconstruction and analysis of glycan-related metabolic pathways.
• Evolutionary studies: Supports analyses of the evolution and diversification of glycosyltransferases across kingdoms.
• Biotechnological application: Informs selection and engineering of GTs for glycoengineering and synthetic biology projects.

Methodology:

Manual curation and compilation of experimentally validated glycosyltransferase activity records into a structured database.