CyanoCyc

CyanoCyc integrates annotated cyanobacterial genome databases with bioinformatics tools for genome, metabolic pathway, and regulatory informatics.

Key Features:

• Genome Database Collection: Contains 277 annotated cyanobacterial genomes supplemented with computational inferences including predicted metabolic pathways, operons, protein complexes, and orthologs.
• External Data Integration: Imports protein features and Gene Ontology (GO) terms from UniProt and other external databases.
• Manual Curation: Five genome databases have undergone manual curation with input from more than a dozen cyanobacteria experts, integrating information from more than 1,765 published articles.
• Comparative Genomics: Provides visualizations of multiple genomes aligned at orthologous genes and comparisons of metabolic networks for multiple organisms.
• Omics Data Analysis: Includes tools for analyzing omics data alongside genome and pathway information.
• Search and Visualization: Enables finding accurate information through search tools and understanding gene function through expert mini-reviews with citations.

Scientific Applications:

• Cyanobacterial Research: Supports fundamental research on cyanobacterial genomes, metabolism, and gene regulation.
• Biotechnology Development: Informs applied research and decision-making for cyanobacterial biotechnology applications.
• Metabolic Pathway Analysis: Enables computational prediction and comparison of metabolic pathways across cyanobacterial species.
• Gene Function Elucidation: Facilitates understanding of gene function through integrated expert-curated information and literature citations.
• Comparative Network Analysis: Supports comparison of metabolic networks across multiple organisms for evolutionary and functional studies.

Methodology:

Computational inference methods predict metabolic pathways, operons, protein complexes, and orthologs; manual curation by domain experts integrates published literature; data is imported from external databases including UniProt.