CyanoMapDB

CyanoMapDB provides a curated compendium of 52,304 experimentally validated protein-protein interactions (PPIs) involving 6,789 proteins from 23 cyanobacterial species to support molecular investigations of photosynthesis, nitrogen fixation, and cyanobacterial systems biology.

Key Features:

• Extensive Data Collection: Contains 52,304 experimentally validated PPIs encompassing 6,789 proteins from 23 cyanobacterial species, compiled from UniProt, STRING, and IntAct.
• Co-fractionation MS-derived Interactions: Integrates novel PPIs identified through co-fractionation mass spectrometry (MS) experiments specific to cyanobacteria.
• Experimental Evidence Annotation: Associates interactions with experimental evidence to distinguish validated PPIs from other data types.
• Network Visualization: Provides visual network representations that depict interaction topology for target proteins.

Scientific Applications:

• Molecular Mechanism Elucidation: Enables identification of protein interaction partners to study molecular mechanisms underlying cyanobacterial functions.
• Photosynthesis and Nitrogen Fixation Research: Supports investigation of protein networks involved in photosynthesis and nitrogen fixation pathways in cyanobacteria.
• Biotechnology and Environmental Studies: Facilitates analyses relevant to cyanobacterial roles in biotechnology and environmental science by revealing interaction-based functional organization.

Methodology:

Compiled and integrated PPI data from UniProt, STRING, and IntAct and supplemented these records with interactions identified by co-fractionation mass spectrometry (MS), followed by data integration and validation.