CyFi-MAP

CyFi-MAP maps molecular mechanisms and pathway modules associated with cystic fibrosis to support analysis of CFTR-related disease variability and therapeutic target identification.

Key Features:

• Disease Map Repository: Provides detailed maps of molecular mechanisms and pathways involved in cystic fibrosis centered on the CFTR gene and its >2100 reported mutations.
• Submap Representation: Distinguishes wild-type CFTR (wt-CFTR) and F508del-CFTR submaps covering protein biosynthesis, endoplasmic reticulum retention, export, channel activation/inactivation, and recycling/degradation after endocytosis.
• Systems Biology Approach: Applies systems biology principles to collect and visualize CF-related molecular data for integrated interpretation of pathway interactions.
• Curated Knowledgebase: Contains curated pathway information specific to CFTR-related processes and is maintained with ongoing updates.

Scientific Applications:

• Disease Variability Analysis: Enables analysis of molecular mechanisms underlying variability in disease severity among individuals with identical CFTR genotypes.
• Mutation-Specific Pathway Analysis: Supports exploration of the cellular impacts of specific CFTR mutations, including F508del, across biosynthesis, trafficking, and degradation pathways.
• Therapeutic Target Identification: Facilitates identification of candidate therapeutic targets by highlighting pathway-level perturbations in CFTR-related networks.
• Personalized Medicine Research: Supports linking mutation-specific pathway alterations to potential intervention strategies for personalized treatment approaches.

Methodology:

Uses systems biology-based collection and visualization of CF molecular data and manual curation to assemble pathway maps distinguishing wt-CFTR and F508del-CFTR.