DASS App

DASS App facilitates the application of three regulatory defined approaches for skin sensitization assessment by integrating data from multiple non-animal tests based on human cells, molecular targets, and computational model predictions using standardized data interpretation procedures.

Key Features:

• Regulatory Testing Strategies: The application implements the Two-out-of-Three (2o3), the Integrated Testing Strategy (ITS), and the Key Event 3/1 Sequential Testing Strategy (KE 3/1 STS).
• Data Upload and Analysis: The application supports upload and analysis of user-provided data.
• Data Quality Checks: The application includes steps to identify inconsistencies and formatting issues.
• Downloadable Predictions: The application provides predictions in a downloadable format.

Scientific Applications:

• Skin Sensitization Assessment: The application identifies potential chemical skin sensitizers for regulatory assessment of chemically induced skin sensitization, or allergic contact dermatitis.
• Non-animal Testing: The application supports regulatory testing strategies based on human cells, molecular targets, and computational model predictions without animal testing.

Methodology:

The application applies standardized data interpretation procedures to integrate data from multiple non-animal tests, with steps to identify inconsistencies and formatting issues in user-provided data.