DAVI

DAVI clusters and visualizes protein domain architectures to support characterization of protein function and evolutionary analysis.

Key Features:

• Clustering: Clusters protein domain architectures to group proteins by shared domain arrangements.
• Visualization: Produces graphical visualizations of domain architectures to enable comparison and interpretation of domain arrangements.
• Input compatibility: Accepts outputs from various domain architecture prediction tools.
• Architecture generation from sequences: Generates domain architectures directly from provided protein sequences.
• Domain and motif focus: Analyzes arrangements of domains and motifs as modular units that influence protein function and evolution.
• Comparative analysis: Facilitates comparison and interpretation of complex domain architecture data for functional and evolutionary inference.

Scientific Applications:

• Protein function characterization: Infers protein function by comparing and clustering domain architectures.
• Evolutionary analysis: Investigates evolutionary history and domain rearrangements through domain architecture comparison.
• Genomics and proteomics studies: Applies to genomics and proteomics datasets for organization and comparison of protein domain architectures.

Methodology:

Accepts outputs from domain architecture prediction tools or computes architectures from input protein sequences, then performs clustering of domain architectures and generates visualizations.