dbCRAF

dbCRAF curates a knowledgebase of 1,677 genes, 49 proteins, and 612 radiosensitizers associated with radiosensitivity, radioresistance, and prognosis in human cancer radiotherapy.

Key Features:

• Curated content: Contains 1,677 genes, 49 proteins, and 612 radiosensitizers annotated for associations with radiosensitivity, radioresistance, and patient prognosis.
• Annotation of radiation response: Links genes, proteins, and radiosensitizers to radiosensitivity, radioresistance, and clinical prognosis based on literature curation.
• Pathway analysis: Provides pathway-level analysis using KEGG (Kyoto Encyclopedia of Genes and Genomes) to contextualize factors in biological processes relevant to radiation response.
• Target identification: Identifies target genes associated with radiosensitivity and radioresistance to inform potential therapeutic targets.
• Analytical modules: Offers modular analysis and relationship exploration between annotated factors and clinical outcomes.
• Integration of evidence: Integrates verified regulatory mechanisms derived from experimental biology and computational analysis.

Scientific Applications:

• Regulatory network elucidation: Elucidates regulatory networks governing cellular radiation response in human cancers.
• Biomarker and target discovery: Supports discovery of biomarkers and therapeutic targets related to radiosensitivity and radioresistance.
• Pathway-informed interpretation: Enables interpretation of radiation response through KEGG pathway context.
• Prognostic association analysis: Facilitates correlation of molecular factors with patient prognosis following radiotherapy.

Methodology:

Integrates manually curated literature annotations and verified regulatory mechanisms from experimental biology with computational analysis and KEGG-based pathway mapping.