dbCRID

dbCRID catalogs chromosomal rearrangement (CR) events associated with human diseases and provides detailed annotations of event types, breakpoint positions, junction sequences, disrupted genes and gene regions, and experimental techniques to support investigation of tumor and non-tumor disease mechanisms.

Key Features:

• Comprehensive Data Collection: dbCRID contains 2,643 records of disease-associated chromosomal rearrangement events curated from 1,172 original studies.
• Detailed Event Documentation: Each entry records the CR event type, associated diseases or symptoms, precise breakpoint positions, junction sequences, disrupted genes and gene regions, and the experimental techniques used to discover and analyze the event.

Scientific Applications:

• Research on DNA breakage and repair: The cataloged CR events support studies into mechanisms of DNA breakage and repair relevant to genomic stability.
• Pathogenesis insights: The annotated events provide information to investigate pathological causes and to identify potential diagnostic markers or therapeutic targets.
• Genetic basis analysis: Researchers can use dbCRID to explore the genetic basis of tumor and non-tumor diseases at the molecular level.

Methodology:

Systematic collection and curation of CR event data from published scientific studies, with manual annotation of each entry for event details and associated disease information.