dbEssLnc

dbEssLnc catalogs essential long non-coding RNA (lncRNA) genes in human and mouse by compiling experimentally supported cases where knockout or knockdown causes lethality or infertility to support studies of essential non-coding genes.

Key Features:

• Manual curation: dbEssLnc contains 207 manually curated essential lncRNA genes compiled from scientific literature.
• Species coverage: Entries include lncRNA genes from human and mouse.
• Evidence criteria: Essentiality is annotated when knockout or knockdown results in lethality or infertility.
• BLAST search support: The database provides BLAST search capability for sequence-level queries against its records.

Scientific Applications:

• Understanding minimal genomes: The collection of essential lncRNAs supports investigation into minimal genomic requirements for cellular viability.
• Drug development and therapeutics: Knowledge of essential lncRNAs can inform identification of potential therapeutic targets and strategies.
• Disease diagnosis and research: Essential lncRNAs in the database can be examined as candidate biomarkers or mechanistic contributors to disease.
• Biological process insights: The resource facilitates study of lncRNA roles in cellular processes and gene regulation.

Methodology:

Manual curation based on an extensive literature review to identify lncRNA genes whose knockout or knockdown causes lethality or infertility.