DBLiPro

DBLiPro provides an integrated knowledgebase and analysis platform for human lipid metabolism by combining curated lipid-associated proteins and lipid metabolites with multi-omics integration for lipidomics, transcriptomics, and proteomics analyses.

Key Features:

• Extensive Knowledgebase: Hosts 3,109 lipid-associated proteins (LAPs) and 2,098 lipid metabolites curated from UniProt, the Kyoto Encyclopedia of Genes and Genomes (KEGG), RaftProt, and PubChem.
• Interactive Bioinformatics Workflow: Provides an interactive, step-by-step workflow for integrative analysis of lipidomics, transcriptomics, proteomics, and multi-omics datasets focused on human lipid metabolism.
• Multi-Omics Integration: Supports integration of lipidomics, transcriptomics, and proteomics data to analyze lipid–protein interactions and their functional mechanisms.

Scientific Applications:

• Discovery of key molecules: Identify critical lipid-associated proteins and lipid metabolites involved in human lipid metabolic pathways.
• Mechanistic investigation: Investigate molecular mechanisms of lipid–protein interactions through integrated omics analyses.
• Biomarker and target identification: Prioritize potential biomarkers, therapeutic targets, and metabolic pathways relevant to lipid-related diseases.

Methodology:

Curates entries from UniProt, KEGG, RaftProt, and PubChem and performs integrative analysis of lipidomics, transcriptomics, and proteomics datasets via an interactive workflow.