dbMisLoc

dbMisLoc catalogs experimentally validated protein mis-localization events and their associated conditions to support research into disease mechanisms and cellular responses.

Key Features:

• Manual curation: Records were manually curated from primary literature to ensure entry-level provenance and experimental validation.
• Comprehensive data records: Each entry reports the protein's normal and mis-localized states, the conditions leading to mis-localization, and literature references.
• Condition categories: Mis-localization events are annotated across 14 categories of conditions, including diseases, drug treatments, and environmental stresses.
• BLAST search integration: The database incorporates a BLAST search engine to enable sequence-based identification of proteins reported as mis-localized.

Scientific Applications:

• Study of disease mechanisms: Enable investigation of how protein mis-localization contributes to complex disorders.
• Biomarker and target discovery: Support identification of candidate biomarkers or therapeutic targets linked to localization changes.
• Comparative and functional analysis: Facilitate sequence-based comparative studies and hypothesis generation via BLAST-derived similarity matches.

Methodology:

Entries were manually curated from the literature and the database integrates a BLAST search engine for sequence-based queries.