DBscorer

DBscorer automates quantitative analysis of rodent behavior in the Forced Swim Test (FST) and Tail Suspension Test (TST) to quantify immobility and mobility states for antidepressant drug screening and assessment of non-motor symptoms in movement disorder models such as Parkinson's disease and Huntington's disease.

Key Features:

• Automation and Accuracy: Automates behavioral scoring of FST and TST to reduce observer-to-observer variability and the time required for manual analysis.
• Customization and Calibration: Provides calibration options to adjust analysis parameters to specific experimental conditions.
• Comprehensive Data Analysis: Quantifies immobility time and produces time-resolved data and graphical representations of immobility and mobility states over the test duration.
• Additional Parameters: Supports extraction and analysis of multiple additional behavioral parameters beyond immobility time.

Scientific Applications:

• Antidepressant screening: Enables quantitative assessment of antidepressant drug effects using immobility metrics from FST and TST.
• Depression-related behavioral analysis: Facilitates measurement of behavioral despair and mobility dynamics in rodent models of depression.
• Movement disorder research: Assists evaluation of non-motor symptoms in rodent models of Parkinson's disease and Huntington's disease.

Methodology:

Automated scoring of FST and TST videos with quantification of immobility time, generation of time-resolved immobility/mobility data and graphical representations, and user-adjustable calibration parameters.