DBSolve Optimum

DBSolve Optimum constructs, simulates, fits parameters for, and dynamically visualizes kinetic models to analyze biochemical system behavior.

Key Features:

• Mathematical model development: Provides tools for creating detailed kinetic models of biological processes.
• Model verification: Includes functionality for verifying model structure and dynamic behavior.
• Parameter fitting: Supports estimation and fitting of kinetic model parameters.
• Numerical simulation: Executes simulations of kinetic models to generate time-course and steady-state behavior.
• Dynamic visualization: Graphical representations of metabolite concentrations and reactions change dynamically in volume and shape according to simulation results.
• Animation of simulation results: Animates simulation timecourses to illustrate kinetic responses and how steady states depend on parameters.

Scientific Applications:

• Systems biology modeling: Construction, analysis, and visualization of kinetic models for systems biology investigations.
• Metabolic pathway analysis: Analysis and visualization of metabolic pathways, exemplified by application to the Krebs cycle.
• Enzyme kinetics: Investigation of enzyme kinetic responses and parameter effects on system behavior and steady states.

Methodology:

Model construction, verification, parameter fitting, numerical simulation, and dynamic visualization that maps metabolite concentrations and reaction activity to graphical volume and shape changes.