DCABM-TCM

DCABM-TCM catalogs blood-absorbed constituents and metabolites of Traditional Chinese Medicine and annotates their physicochemical properties, ADMET profiles, and associations with molecular targets, functional terms, pathways, and diseases to support molecular mechanism analysis and drug discovery.

Key Features:

• Content scope: Contains 4,206 blood constituents collected from 192 prescriptions and 194 herbs.
• Absorption context: Focuses on constituents absorbed into the bloodstream as original compounds or as metabolites produced by the gastrointestinal tract, intestinal microflora, and liver.
• Data acquisition: Systematically compiles constituent information through literature mining.
• Annotations: Provides physicochemical properties and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) properties and links to targets, functional terms, pathways, and diseases.
• Analytical functions: Implements network pharmacology analysis and target/pathway/disease-based screening to identify candidate blood constituents, herbs, or prescriptions.
• Categorization: Organizes data into six scientific categories: prescriptions, herbs, blood constituents, targets, pathways, and diseases.

Scientific Applications:

• Molecular mechanism elucidation: Uses network pharmacology analysis to investigate molecular mechanisms of TCM prescriptions and herbs.
• Drug candidate screening: Performs target-, pathway-, and disease-based screening to identify candidate blood constituents, herbs, or prescriptions for drug development.
• Bioactive compound discovery: Supports identification of bioactive and bioavailable drug-like compounds derived from TCM constituents and metabolites.
• Quality control support: Informs quality control of herbal products through characterization of absorbable constituents and metabolites.
• Absorbable compound investigation: Enables study of features and roles of natural compounds that are absorbable into blood.

Methodology:

Data were compiled by literature mining and annotated with physicochemical properties, ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) properties and associations to targets, functional terms, pathways, and diseases; the resource provides network pharmacology analysis and target/pathway/disease-based screening.